Depression & Treatment-Resistant Depression
When depression persists, understanding your options matters.
Depression can affect mood, energy, concentration, motivation, and everyday functioning. When symptoms continue despite previous treatment, it may be time to reassess the care plan with a qualified professional.
When to reassess
When symptoms continue despite previous treatment, it may be time to reassess the care plan with a qualified professional.
Understanding depression
Depression does not look the same in two people.
Depression is a complex mental-health condition that affects people differently. Symptoms can vary in type, intensity, and duration, and treatment needs can change over time.
- Mood
- Energy
- Concentration
- Motivation
- Everyday functioning
Two people with the same diagnosis may need two different plans.
Assessment starts with the individual.
A term worth understanding
What does treatment-resistant depression mean?
Treatment-resistant depression generally refers to depression that has not improved adequately after appropriate treatment attempts.
Clinical definitions vary, and determining whether someone meets the criteria requires professional evaluation.
Held lightly
The label describes a pattern, not a person's prospects.
Because definitions differ between clinicians and sources, the term is most useful as a starting point for a review of treatment history — not as a conclusion about what is or isn't possible.
Only a qualified clinician can determine whether the criteria are met.
A second look
Why reevaluation may help.
A psychiatric evaluation may help clarify the diagnosis, review medication trials and therapy history, identify other contributing factors, and determine whether different treatment options warrant consideration.
Request an Evaluation
- 1
Clarify the diagnosis
A psychiatric evaluation may help clarify the diagnosis.
- 2
Review what has been tried
It reviews medication trials and therapy history.
- 3
Look for other factors
It identifies other contributing factors.
- 4
Consider what comes next
It determines whether different treatment options warrant consideration.
Possible directions
Exploring care options.
Depending on clinical circumstances, options may include psychotherapy, medication management, Spravato, off-label ketamine treatment, or other appropriate approaches.
Not every option is appropriate for everyone. Eligibility and suitability are determined by a qualified clinician after evaluation.
- PsychotherapyTherapy and counseling to explore thoughts, emotions, and coping strategies.
- Medication ManagementOngoing review of medication needs, responses, and adjustments with a prescriber.
- Spravato (esketamine)A prescription nasal spray with FDA-approved indications for certain depressive conditions.
- Off-label ketamine treatmentAn approach used off-label in psychiatric care, considered after clinical evaluation.
- Psychiatric evaluationAn assessment of symptoms, history, and treatment needs — often where care begins.
Begin with a conversation
Your treatment history deserves a thoughtful review.
Speak with the Neurobody team in Atlanta. Every conversation begins with a thorough psychiatric evaluation — not a quick decision.
Request an EvaluationEducational information only. All treatment decisions are made by qualified clinicians.